BrighteLife Laboratoryies- Immunogenyx

The immune system has evolved to discriminate self from non-self, thereby protecting the host from infection and malignancy.

Nevertheless, a breakdown in this immune-regulatory process often results in the pathogenesis of chronic infectious diseases, malignant tumors and autoimmune diseases. While pro-inflammatory cytokines promote pathogenesis of organ-specific autoimmune diseases, anti-inflammatory cytokines confer recovery.

We investigate the expression and function of cytokines, chemokines, adhesion molecules, their receptors and associated signaling pathways in Th1/Th17 cell-mediated autoimmune disease models. We determine the pathogenic mechanisms and develop novel therapies for immunological disorders.

We investigate the mechanisms of immune evasion in cancer and cancer stem cells and identify protective tumor antigens to develop cancer immunotherapy. We determine the mechanisms of signaling pathways in mediating protective cancer immunity.

We provide collaborative contract research and bioassay services to detect cytokines and immune mediators, immune cell based assay services to identify effective drugs and in vivo drug testing services using autoimmune and inflammatory disease models.

We also provide in vitro cancer cell and cancer stem cell based assay services to identify effective tumor antigens in culture and in vivo cancer xenograft models.